An experimental study on the hepatotoxicity of Arcangelisia flava (albutra) in rats
Mendoza SM, Abola LE, Guevara MC, Alcon JH
OBJECTIVE: This study was undertaken to determine if Arcangelisia flava is hepatotoxic in rats.
METHODS: Thirty rats were randomly divided into 3 groups: a control group and 2 experimental groups. The freeze dried preparation of Arcangelisia flava was administered intraperitoneally for each study group at a dose of 125 mg/kg and 375 mg/kg respectively while the control group received 1.0 ml of saline solution. Serum alanine aminotransferase levels and liver histology, taking into consideration blood vessel and hepatocyte changes were then obtained 48 hours after drug administration.
RESULTS: Only an isolated case of SGPT elevation was noted whereas majority of the levels were within normal range. The difference between groups was not statistically significant between groups. Hepatocyte changes ranged from between fatty infiltration to frank necrosis and the difference was noted to be statistically significant between groups.
Serum alanine aminotransferase levels were not significantly elevated after administration of Arcangelisia flava in rats. Blood vessel changes were likewise not supportive of the presence of hepatotoxicity. The significant changes in the hepatotoxicity secondary to the test drug or result from other factors beyond the scope of this study.
|Plant local name||Abutra|
|Scientific name||Arcangelisia flava|
|Is local study?||Yes|
|"herbs.ph" plant grouping||2|
|"herbs.ph" plant name ID||ABT4|
|Type of study||For classification|
|Full text available?||Yes|
|Full citation||Mendoza SM, Abola LE, Guevara MC, Alcon JH. An experimental study on the hepatotoxicity of Arcangelisia flava (albutra) in rats. UERMMMC Journal of Health Sciences 2000;3(1):9-14.|