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Title

Benzodiazepine agonist-type activity of raubasine, a rauwolfia serpentina alkaloid

Author:        

Charveron M, Assie MB, Stenger A, Briley M

Abstract

Raubasine produced a dose-related inhibition of specific [3H]flunitrazepam binding to rat brain membranes. Scatchard analyses revealed a significant increase in the affinity constant but no change in the number of binding sites, suggesting that raubasine act as a competitive inhibitor. Raubasine also inhibited the in vivo binding of [3H]flunitrazepam to mouse brain sites. Behavioral studies showed raubasine to possess anticonvulsant properties against pentylenetetrazol- and bicuculline-induced convulsions in mice. These effects were inhibited by the benzodiazepine antagonist, Ro 15-1788. The results suggest that raubasine interacts directly at benzodiazepine sites with a benzodiazepine agonist-type activity.

Conclusion

Plant local nameSerpentina
Scientific nameRauwolfia serpentina
Is local study?
"herbs.ph" plant grouping3
Abstract availabilityYes
"herbs.ph" plant name IDSPT17
CategoryCompleted
Type of studyFor classification
Full text available?
Full citationCharveron M, Assie MB, Stenger A, Briley M. Benzodiazepine agonist-type activity of raubasine, a rauwolfia serpentina alkaloid. Eur J Pharmacol 1984;106(2):313-317.