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Title

Alterations in cardiovascular responses of the dog following Rauwiloid. an alkaloidal extract of Rauwolfia serpentine

Author:        

Gourzis JT, Sonnenschein RR, Barden R

Abstract

Rauwiloid? an alkaloidal extract representing the total activity of the root of Rauwolfia serpentina, Benth., was administered orally for 5 days to 15 normo-tensive dogs. The following observations (compared to 15 control animals) were obtained on the sixth day: 1. There was a significant decrease in MAP and heart rate. 2. Eleven of 15 animals were sedated. 3. The pressor response to epinephrine was augmented. 4. The hypotensive and cardio-accelerator effects of isopropylnorepinephrine (Isuprel) were enhanced. 5. The blood pressure rise generally evoked by hypoxia was reversed. 6. The carotid sinus pressor reflex was diminished. 7. Blockade of the primary blood pressure rise elicited by faradization of the afferent vagus occurred; the secondary rise was essentially unaltered. 8. The hypotensive responses to acetylcholine, histamine and efferent vagal faradization were not altered.

Conclusion

Plant local nameSerpentina
Scientific nameRauwolfia serpentina
Is local study?
"herbs.ph" plant grouping3
Abstract availabilityYes
"herbs.ph" plant name IDSPT18
CategoryCompleted
Type of studyFor classification
Full text available?
Full citationGourzis JT, Sonnenschein RR, Barden R. Alterations in cardiovascular responses of the dog following Rauwiloid. an alkaloidal extract of Rauwolfia serpentine. Exp Biol Med 1954;85(3):463-466.