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Title

The anti-emetic activity of alkaloids of Rauwolfia serpentina

Author:        

Malhotra CL, Sidhu RK

Abstract

Reserpine and alseroxylon were tested in dogs to determine their anti-emetic action against apomorphine-induced emesis. The Rauwolfia alkaloids were also tested against emesis induced by morphine, ergot (Hydergine), veratrum and oral copper sulphate.
Reserpine and alseroxylon are markedly effective in antagonizing apomorphine-induced emesis. They also protect against vomiting evoked by morphine and ergot, but they are ineffective against emesis induced by veratrum and oral copper sulphate. The pattern of anti-emetic action suggests that the mechanism of action is a selective depression of the medullary emetic chemoreceptor trigger zone.

Conclusion

Plant local nameSerpentina
Scientific nameRauwolfia serpentina
Is local study?
"herbs.ph" plant grouping3
Abstract availabilityYes
"herbs.ph" plant name IDSPT28
CategoryCompleted
Type of studyFor classification
Full text available?
Full citationMalhotra CL, Sidhu RK. The anti-emetic activity of alkaloids of Rauwolfia serpentina. JPET 1956;116(1):123-129.