The anti-emetic activity of alkaloids of Rauwolfia serpentina
Malhotra CL, Sidhu RK
Reserpine and alseroxylon were tested in dogs to determine their anti-emetic action against apomorphine-induced emesis. The Rauwolfia alkaloids were also tested against emesis induced by morphine, ergot (Hydergine), veratrum and oral copper sulphate.
Reserpine and alseroxylon are markedly effective in antagonizing apomorphine-induced emesis. They also protect against vomiting evoked by morphine and ergot, but they are ineffective against emesis induced by veratrum and oral copper sulphate. The pattern of anti-emetic action suggests that the mechanism of action is a selective depression of the medullary emetic chemoreceptor trigger zone.
|Plant local name||Serpentina|
|Scientific name||Rauwolfia serpentina|
|Is local study?|
|"herbs.ph" plant grouping||3|
|"herbs.ph" plant name ID||SPT28|
|Type of study||For classification|
|Full text available?|
|Full citation||Malhotra CL, Sidhu RK. The anti-emetic activity of alkaloids of Rauwolfia serpentina. JPET 1956;116(1):123-129.|