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Title

Antiarrhythmic activity of ajmaline obtained from Rauwolfia serpentina biomass grown in tissue culture

Author:        

Kostin IaV, Tsybusoy AP, Minina SA, Kuznetsova VA, Borodulina MV, Balashov VP

Abstract

The conventional experimental techniques showed that ajmaline derived from Rouwolfia serpentina Benth. biomass grown in tissue culture was effective in arresting canine ventricular arrhythmias induced by coronary occlusion, strophanthin and epinephrine, displaying antiarrhythmic effects inaconitine-induced intoxication of rats and substantially elevating the threshold of ventricular fibrillationsin cats. The antiarrhythmic activity of ajmaline produced by the biotechnological technique was identical to that of ajmaline derived from the natural root of Rauwolfia serpentina Benth, which allows one to recommend that the agent in question should be clinically tested as an antiarrhythmic.

Conclusion

Plant local nameSerpentina
Scientific nameRauwolfia serpentina
Is local study?
"herbs.ph" plant grouping3
Abstract availabilityYes
"herbs.ph" plant name IDSPT29
CategoryCompleted
Type of studyFor classification
Full text available?
Full citationKostin IaV, Tsybusoy AP, Minina SA, Kuznetsova VA, Borodulina MV, Balashov VP. Antiarrhythmic activity of ajmaline obtained from Rauwolfia serpentina biomass grown in tissue culture. Kardiologiia 1990;30(8):72-74.